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Nicotine-independent mechanisms have been reported in several e-cigarette health effects, including induction of oxidative stress and DNA damage in oral cell lines 36 , disruption of lung lipid homeostasis and innate immunity in mice 57 , and impairment of vascular reactivity and endothelial function in healthy nonsmokers 58
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Little is known about how these changes in cigarette consumption have varied across subgroups of smokers
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