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Abstract Electronic cigarettes (e-cigarettes) have emerged as a healthier alternative to conventional cigarettes, gaining popularity due to their perceived reduced harm and modern appeal

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Whereas only 23% of estradiol circulates freely and this small percentage of E2 is able to enter the cell and bind to steroid receptors

Since May 2020, a European regulation requires health warnings and shocking images to cover 65% of the front and back surface of cigarette packs

Oncotarget 7(48):7898578993 Mack PC et al (2022) Targeted Next-generation sequencing reveals exceptionally high rates of molecular driver mutations in never-smokers with lung adenocarcinoma

It is caused by build-up of plaques in the blood vessel wall