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References available on request by: Foley E1, MB BCh BAO MRCPI, Respiratory SPR Interventional Respiratory Unit, Galway University Hospital, Lead Galway University Hospitals 1

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Importantly, plant viruses do not replicate in vertebrate hosts and are generally regarded as biologically non-infectious for humans ( 6 A mechanistic hypothesis: TMV-mediated epithelial pre-activation We propose that chronic exposure to TMV-containing aerosols may function as a non-infectious, persistent, low-intensity pathogen-associated exposure at the respiratory mucosa