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While not a perfect translation, this model could be used to represent a lifelong user. The introduction of e-cigarettes might have done a fair job of reducing the incidence of cigarette smoking, but has this come with a cost

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Participant guess about treatment arm assignment may influence outcome in a clinical trial of bupropion for smoking cessation

High Blood Press Cardiovasc Prev 27 , 349362 (2020)

A proposed theory seeking to explain this refers to the intimidating aura that smoking is thought to create: thus, in an apparent effort to gain greater deterrence, a larger number of individuals belonging to this sector adopt the habit of smoking