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Chronic exposure to this smoke causes metaplastic alterations to the respiratory mucosa with an increase in the number and size of goblet cells and consequent increase in upper airway secretion.17,18 Cohen et al.13 and Kreindler et al.19 also showed in vitro that exposure to cigarette smoke inhibits chloride transport in epithelial cells, causing physiological alterations similar to those found in patients with cystic fibrosis

Smoke Breath Pack 1 Smoke Breath - Pack 1 Front-facing smoke breath effects work well to mimic exhaled cigarette smoke, when the person is directly facing the camera
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Flavoring agents, often perceived as harmless, can also exert cytotoxic effects
