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In particular, taking high doses constantly and over an extended period can cause the brain to produce less dopamine instead

That will involve exposing cells to e-cigarette aerosols and determining the specific effects of these radicals on important cell functions

Remember, THC is an intoxicant

Routine screening is not currently recommended, but may be beneficial in individuals at high risk, such as heavy smokers
Second, smoking status and tool usage were self-reported, which introduces the risk of response and recall bias
