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2013 saw the introduction of official vape regulations in Europe, with amendments made to the EUs Tobacco Products Directive (TPD) and the UK Medicines and Healthcare Products Regulatory Agency (MHRA) announcing it will regulate e cigs as medicines
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There are eighteen peaks of more than 3,000 metres (9,800 ft) in the South Island

While this possible bias most likely did not affect effect sizes and their directions in the models due to the size of the studied cohort, it may have altered the width of the confidence intervals and thus the statistical significance of some findings

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