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The brain responds to long-term nicotine exposure by increasing the number of nicotinic acetylcholine receptors (nAChRs), while simultaneous changes in glutamate and GABA signaling boost excitatory signals to dopamine neurons

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Suffice to say, I had a great time, despite the two drunken dancing lesbians who partially impaired my view and the elderly couple who sat in front of me completely stone-faced with their arms crossed the entire show

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