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Gambogic acid counteracts mutant p53 stability by inducing autophagy

It is well recognized that the mechanisms of ROS induce apoptotic cell death via the upregulation of p53 function by increasing ubiquitin-dependent MDM2 degradation and thereby reducing p53 degradation 85

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Control cells were given an identical concentration of the diluent DMSO, as found in the experimental samples

Qian Y, Chen X