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While nicotine is addictive, the combusted tobacco is what causes negative health effects, such as cancer, emphysema, and heart disease

Limitations The present study has some inherent limitations

The tobacco plug is made from tobacco leaves, which are ground and reconstituted into tobacco sheets, called cast-leaf

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- Elegant Appeal : The sleek packaging and modern flavor make Marlboro Advance an attractive choice for smokers who value both innovation and quality