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Prolonged smoking has also been shown to change the morphology of cardiac muscles, leading to the development of LV hypertrophy from young adulthood to middle age (57)

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Second, the particulate components of CSE activate protein kinase C (PKC), resulting in increased expression of the peripheral blood monocyte adhesion ligand CD11b and endothelial cell counter receptors VCAM1, ICAM-1 and ELAM-1