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during this process, a large amount of oxidized lipids, mtDNA, and DAMPs such as HMGB1 are released, activating alveolar macrophages and dendritic cells via TLRs/NLRs, driving the upregulation of IL-6, TNF-, CXCL8, and promoting sustained recruitment of neutrophils, forming a positive feedback loop of iron load lipid peroxidation inflammation (120)

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It primarily eats into the relatively healthy years in midlife, bringing forward the onset of ill-health