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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Louie K.S., Castellsagu X., De Sanjose S., Herrero R., Meijer C.J., Shah K., Muoz N., Bosch F

Over time, the brain becomes accustomed to nicotine, leading to cravings when levels drop

At the positive end of the spectrum lies Sweden, the prime example of sensible policy which embraces Tobacco Harm Reduction (THR)

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Jamestown lost at least 80% of its population between 1607-1610 CE