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(1) uninfected macrophages express anti-inflammatory responses, including polarization of CD206 + M2 macrophages and increased expression of IL10, whereas (2) infected macrophages show inflammatory responses, including differentiation to M1 macrophages and increased expression of iNOS, TNF-, and IL6

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However, it is generally described as the specific treatment of someone diagnosed with a substance use disorder and a mental health disorder simultaneously