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So when I look out at the world outside of my own home, I am reassured to find that even our most disposable objects are the result of staggering quantities of serious and earnest engineering work

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In AD, a vicious cycle forms among A aggregation/Tau hyperphosphorylation, mitochondrial dysfunction , and defective mitophagy, each process exacerbating the others and accelerating disease progression [346, 429, 430]

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