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The benchmark dose values ranged from 2 mg/kg bodyweight for heroin to 531 mg/kg bodyweight for alcohol (ethanol)
Since their commercial introduction in the mid-2000s, e-cigarettes have been adopted by millions of people worldwide and are frequently promoted as less harmful alternatives to combustible tobacco products [4,5,6]

NJOY has now become the first brand of menthol e-cigarettes approved by the FDA, but it is not the first brand to attempt to pass the PMTA (Premarket Tobacco Product Application)