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Description
p53: Traffic cop at the crossroads of DNA repair and recombination
Mol Cancer Ther
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BMC Public Health
Under conditions of cellular homeostasis, the stability and function of p53 protein are controlled by MDM2 that targets p53 for degradation and directly inhibits p53 activity by binding to the transcriptional activation domain 17
Furthermore, histological staining of mutant p53 proteins in over 100 SCLC tumour specimens revealed that the presence of mutant p53 is associated with poor patient survival, supporting the role of mutant p53 as a predictive marker of poor prognosis in SCLC [165]
Durability and Performance
