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Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype
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Later work demonstrated that the combined absence of the p53 target genes encoding the pro-apoptotic BH3-only proteins PUMA and NOXA (and to a lesser extent loss of PUMA alone) rendered lymphoid cells as resistant to DNA damage-inducing agents as loss of p53 itself [8, 9, 22]

[7] Dopamine and endorphins are released, which are often associated with pleasure, [8] leading to addiction

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1984 Chemical Carcinogens
