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These companies grew their bottom lines by raising prices to offset declining shipments, cutting costs, expanding into adjacent markets like e-cigarettes, and consolidating the market

The cumulative impact of net inbound smuggling over the historical period, $83.8 billion, is much greater than the cumulative impact of net outbound smuggling, at only $4.31 billion

Patients were randomized to receive lorazepam 2 mg IV (with an additional 2 mg IV if needed) or diazepam 5 mg IV (with an additional 5 mg IV if needed)

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Late 20th Century By the late 20th century, the awareness of smoking's health risks increased, and governments had begun heavily restricting cigarette marketing

Comparison to Reference product: Applicant to demonstrate the product meets a defined standard or deviates from a standard with justification