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Although FA treatment could not fully mimic effects of maternal smoking and MSCS, our findings indicate that FA can exacerbate APAP-induced hepatotoxicity in vitro , primarily through modulation of miR-34a-5p expression, consistent with in vivo observations

Genes upregulated in smoke exposed tumors mapped to GO pathways related to: (1) negative T cell selection, (2) regulation of NK cell mediated immunity and (3) negative regulation of lymphocyte mediated immunity among others (Supplemental Table XX)