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Nicotine, the primary addictive component of tobacco, acts on nicotinic acetylcholine receptors in the brain, leading to the release of dopamine and other neurotransmitters associated with pleasure and reward

Casanova has received speaker or consulting fees from AstraZeneca, Bial, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Menarini and Novartis, and research grants from GlaxoSmithKline, Menarini and AstraZeneca