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One widely used commercial assay, the HerpeSelect HSV-2 EIA, has an overall specificity of about 57 percent, dropping to roughly 40 percent for borderline-positive index values in the 1.1 to 2.9 range, per real-world data cited in the CDC STI Treatment Guidelines

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Also, we have not controlled for all possible confounders and thus some residual confounding remains

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