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Annals of Internal Medicine 2001;135:42333

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DISCUSSION Despite the strong and consistent epidemiological evidence linking cigarette smoking to several CVDs and liver diseases 27 , the association between smoking intensity and changes in CVD risk factors remains unclear

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The relevance of HER2 amplification and/or overexpression in NSCLC is less clear, and efforts to target HER2 in patients with NSCLC have been focused mostly on those harbouring activating HER2 mutations, approximately 5458% of which occur in patients who have never smoked 128,129