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When you smoke a cigarette, nicotine is delivered directly to your brain

And we were the pioneer there

Furthermore, studies indicate a lack of standardization in optimal cotinine cut-off values, making it difficult to differentiate smokers, passive smokers, NRT users, and non-smokers

Smoking is the top preventable cause of death and disease in the U.S

Similarly, improving emissions standards for road vehicles between 2005 and 2018 reduced the health impacts from road pollution by 50%, from around 37,000 to 18,000 early deaths per year

Thus cellular mechanisms leading to a reduction in cisplatin-induced DNA damage are key factors in the development of cisplatin resistance 41
