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The semaglutide vs tirzepatide side effect comparison reveals that tirzepatide users may experience slightly different GI symptom profiles, with tirzepatide diarrhea being somewhat more common in clinical trials

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15 Phase II trials targeting MASH have shown that treatment with SEMA 0.4 mg daily for 72 weeks resulted in more patients with liver fibrosis stage F2/F3 achieving improvement in MASH without progression of liver fibrosis (odds ratio = 6.87, 95% CI = 2.6017.63) compared to placebo

NICE guidance (NG28) supports the use of GLP-1 receptor agonists like semaglutide in combination with other glucose-lowering therapies, including sulfonylureas, when clinically appropriate and within specific criteria