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During thelarche in females, the initial clinical appearance of the breast bud and growth and division of the ducts occur, giving rise to club-shaped terminal end buds, which then form alveolar buds

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Since cyst(e)inase treatment can induce intracellular cystine degradation consequent promotion of cancer cell ferroptosis [88], the combined cyst(e)inase with PD-L1 antibody effectively enhances tumor immunotherapy [86], suggesting that combined ferroptosis inducers with immune checkpoint inhibitors could effectively enhance cancer immunotherapy

Thus, a direct cause/effect relationship between GSH depletion and apoptosis was evidenced in neuronal cell [54]