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10.1053/j.gastro.2013.04.056 185

[2] It has also been associated with higher rates of Down syndrome and birth defects in offspring of those with the MTHFR gene variation, as well as other issues that may manifest later on in life, such as an increased risk of blood clots and a higher risk of certain cancers
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Ma, W., Saunders, P
The brain atrophy of GCLC-KO mice was also evidenced by MRI analyses (Fig