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Meanwhile, another metabolite derived from the TCA cycle intermediate fumarate, dimethyl fumarate, can also inhibit aerobic glycolysis by targeting GAPDH, potentially promoting cuproptosis
Blood Cancer J Dual therapeutic targeting of MYC and JUNB transcriptional programs for enhanced anti-myeloma activity
50 50 & Target IC50: 140 nM (human MPO) [1] In Vitro AZD5904 is a pselective and irreversible inhibitor of human Myeloperoxidase (MPO) with an IC 50 of 140 nM and has similar potency in mouse and rat
