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Proc Natl Acad Sci USA 109:79747981 Rashidi-Nezhad A, Talebi S, Saebnouri H, Akrami SM, Reymond A (2014) The effect of homozygous deletion of the BBOX1 and Fibin genes on carnitine level and acyl carnitine profile

Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation

It's typically not recommended for pregnant or breastfeeding women without specific medical advice

33 Most of those deaths were related to cardiovascular or infectious causes, possibly because antipsychotics can prolong QT interval and cause sedation, which may increase the risk of aspiration

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Nevertheless, in 2003 a systematic review concluded there was insufficient evidence to recommend a clinical use, although a meta-analysis in the same year showed a significant advantage for ALC for clinical scales and psychometric tests