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However, in agreement with a causal role of moderately elevated circulating homocysteine levels in cardiovascular disease, some putative mechanisms have been identified that may explain the atherothrombogenicity of hyperhomo- cysteinemia

Identification and characterization of potent, selective and metabolically stable IKKbeta inhibitor

Autophagy can be triggered by TMZ in glioma cells and reactive astrocytes of glioma patients [261]
High levels of oxidative stress can lead to "stiffness" in the arterial walls

10.1016/j.mito.2016.06.006 111
Furthermore, CHAC1 induction is directly suppressed by m 6 A methylation
