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The synthesis of new tricyclic imide ligands can be achieved by the reaction of compound 110 with 3-aminopiperidine-2,6-dione hydrochloride, in THF under reflux (Scheme 15) 58,162

Together, these epigenetic modifications help restore immune tolerance and may reduce SLE flares (152)

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Mehandru, S., Tenner-Racz, K., Racz, P., et al

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