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KEAP1-dependent NRF2 activators Electrophilic compounds The most known NRF2 activators are electrophiles electron-deficient species able to form covalent bonds with electron-rich nucleophiles through a variety of chemical pathways which can covalently bind and modify cysteine residues in KEAP1 [273, 274]

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Cell Mol Neurobiol 43 , 27432759 (2023)

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Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) recognizes peptidoglycans from the bacterial wall and suppresses commensal bacteria extension, such as Enterobacteriaceae, Clostridiales, and Bacteroides spp