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When co-exposed, these mechanisms act synergistically, potentially resulting in greater BBB disruption than single exposures, exhibiting an additive effect

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Appetite 58: 767770, 2012

doi: 10.1016/j.canlet.2019.05.027

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Studies in metabolic and toxicological models indicate that co-activation of PPAR and NRF2 provides synergistic protection against oxidative damage, thereby reducing secondary NF-B activation [92]