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AT-101, a natural compound from cotton seeds, induced excessive mitophagy in glioma cells by upregulating the expression of heme oxygenase 1 (HMOX1) and the mitophagy receptors BNIP3 and BNIP3L [61]

Abstract The regulation of the redox status involves the activation of intracellular pathways as Nrf2 which provides hormetic adaptations against oxidative stress in response to environmental stimuli

That means we should be careful about big promises

Limited bloodbrain barrier penetration and the immunosuppressive tumor microenvironment may have contributed to these limited results

Funding This work was supported by the DFG-funded Research Unit FOR 5098 Innovation and Coevolution in Plant Sexual Reproduction (JI, ST, SS, TD, SJMS)

Sci Pharm 15:85 Koksal E, Bursal E, Gulcin I, Korkmaz M, alayan C, Goren AC, Alwasel SH (2017a) Antioxidant activity and polyphenol content of Turkish thyme ( Thymus vulgaris ) monitored by LC-MS/MS
