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There is no indication of severe adverse effects resulting from exogenous melatonin intake

F.CiofuO.KirkbyN.ChristiansenL

GH excess is much rarer than GH deficiency in childhood and can be caused by pituitary adenomas, optic nerve gliomas (seen predominantly with NF1), McCune Albright syndrome, or Carney complex

[PubMed] [Google Scholar] Gamulin O, Serec K, Bili V, et al

Food Chem Toxicology: Int J Published Br Industrial Biol Res Association 148:111937

This work describes the role of extracellular thiol oxidoreductases in redox signalling