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Researchers at those dose levels either need to split the dose into two injections or use a different reconstitution volume

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3.1 Primary GH insensitivity 3.1.1 Growth disorders related to GHR defects Mutations of GHR represent the most frequent cause of primary GHI syndrome, clinically characterized by severe short stature, with a height up to 10 standard deviations (SDs) below normal, and severe IGF-1 deficiency (28)

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NETs release a large amount of enzymes, including NE, which contributes to tissue degranulation, impaired bacterial clearance, and increased mucus production.23 Consequently, they have distinct prognostic implications, indicating a promising avenue for tailored treatment strategies