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"Sirturo (bedaquiline) Tablets

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Pader I, Sengupta R, Cebula M, Xu J, Lundberg JO, Holmgren A, Johansson K, Arner ES

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Jain S

Owing to the pronounced mutagenicity and the carcinogenic potential of many NAs, NA impurities in pharmaceuticals are designated as a "cohort of concern" under the ICH M7(R2) guideline, for which the corresponding Threshold of Toxicological Concern (TTC) approach is not considered appropriate (European Medicines Agency 2025)

To ensure that that each mutation did not significantly alter the tertiary structure of GLRX, we carried out 400-ns-long MD simulations

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