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Whilst B12 is undeniably important for maintaining normal metabolic function, the relationship between vitamin B12 and weight loss is frequently misunderstood

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Only one Phase I clinical trial has been registered, and no Phase 2 or 3 trials have been completed

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Among the 25 studies included in the qualitative synthesis (16 in the meta-analysis), 15 focused specifically on serum cobalamin changes (reported by baseline and post-treatment means and standard deviations in pg/mL) and 10 reported homocysteine outcomes (means and standard deviations in mmol/L)