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discontinue use if severe symptoms occur

It also cannot be explained by another sleep disorder, coexisting mental or medical disorders, or medication

Some of these regulated genes, such as phospholipases A1 and A2 (PLA1, PLA2) and phospholipase D (PLD), contribute to the synthesis of lysophospholipids, in general, and phosphatidic acid, in particular [22]

This makes the combination appealing not just for weight loss but for anyone looking to improve their long-term health

Follow-up work showed that ketogenic diets also induce nuclear accumulation of the NF E2-related factor (NRF2) transcription factor (Milder et al., 2010), which is a master regulator of the cellular antioxidant machinery (Yamamoto et al., 2018)