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In Australia, the ratio is approximately 1 in 17,000, and in Zimbabwe, the prevalence is approximately 1 in 1,000

Reported side effects were edema and mild subconjunctival hemorrhages which resolved after a few days and 2 weeks, respectively [75]

and EU, it is not approved and considered unregulated

83 A trial comparing the daily and weekly formulations of setmelanotide in patients with gene defects in the MC4R pathway is also underway
