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On the other hand, mitochondria-related mechanisms of apoptosis activation prevail over the antiapoptotic mechanisms in this disorder [16, 158, 199]

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Serotonin promoted hepatocyte proliferation in vivo after APAP challenge As the former study showed that serotonin could promote the liver regeneration and hepatocyte proliferation after partial hepatectomy and hepatic ischemia/reperfusion injury 15,16 , we hypothesized that serotonin might also increase hepatocyte proliferation after the APAP overdose