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However, the substantial structural changes that occur in the development of the IVD and the inherent heterogeneity of the fully formed NP, including the differences in cell population between mouse and human samples have made distinctly defining the ultimate mature NP cell profile a difficult task

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When lymph builds up because lymph vessels or nodes that the fluid travels through are missing, damaged, or removed, that buildup is called lymphedema

Prolonged diagnostic pathways may also contribute to disease progression, including the development of deep infiltrating disease and adhesions, which can complicate treatment and reduce reproductive outcomes