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Apart from its therapeutic role in diabetic patients, pioglitazone has been reported to upregulate the expression of enzymes (such as superoxide dismutases) involved in metabolic pathways in the mitochondria via the activation of PPAR ( 5.1.4 MIN-102 (leriglitazone) Leriglitazone is a metabolite of pioglitazone and a PPAR agonist which has been reported to have a good bioavailability in the central nervous system coupled with a better safety profile

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In control, olive oil, and CCM-treated groups, a weak NF-B positive reaction in the cytoplasm of fibrocyte of spiral ligament and a negative reaction of epithelial layers of stria vascularis were recorded (Fig

The absence of standardized outcome measures across studies further complicates evidence synthesis and interpretation