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Due to great success, DBS (Deep brain stimulation) in the subthalamic nucleus (STN) and globuspallidus internus (GPi) is currently the most popular therapy (Rocchi et al., 2012

PncA, a nicotinamidase that converts nicotinamide (niacin) to nicotinic acid, is needed to provide a precursor for biosynthesis of NAD (Purser et al., 2003)

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As the number of organelles increases, there is difficulty in the preparation of therapeutically efficient designs

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