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Overall, these findings offer substantial preclinical evidence supporting the use of UA as a novel immunomodulator to enhance cancer immunosurveillance and improve the bodys ability to combat cancer

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Tras la administracin por sonda a ratones o ratas de 1,2-dibromoetano en dosis de 37 a 107 mg/kg de peso corporal al da (promedio ponderado por el tiempo) durante un periodo de 49 a 90 semanas, o la administracin a ratones en dosis de 103 a 117 mg/kg de peso corporal al da en el agua de beber durante un periodo de 15 a 17 meses, se observaron cambios no carcinognicos tales como degeneracin heptica, atrofia testicular, y acantosis e hiperqueratosis del preestmago, adems de mortalidad

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Conversely, in other investigations, leptin was found to be involved in the development and progression of many autoimmune conditions [129,130]