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Furthermore, in vitro conditions lack the host immune response, mucus layer, and interactions with other microbial species that would modulate the probiotic function and survival in vivo

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doi: 10.4103/0019-5359.29592 215
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365 Although kifunensine has been described as a suppressor of the UPR in several studies, it is more likely that it reduces the perceived level of ER stress by preventing misfolded glycoproteins from being recognized as defective, thereby limiting their degradation through the ERAD pathway
