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It can be supplied by the diet, but cholesterol biosynthesis de novo occurs in the liver, brain and at sites of major consumption, such as the adrenals, which use cholesterol as precursor for steroid biosynthesis

Third, choline is essential for assembling phosphatidylcholine , the phospholipid required for VLDL formation

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suggest that the biopsy sample of lingual melanotic lesions include normal tissue so that it is easier to compare the normal pigmentation with that of the lesion.2 Although lingual melanotic macule is a benign condition, an important differential diagnosis is made with melanoma

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