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7 8 The decisive lesson is that human trials measure the endpoint that matters net weight and fat change in real people and at that bar the compound did not perform, regardless of how clean the upstream lipolysis readouts looked

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Asymptomatic patients with borderline levels may benefit from trial therapy if metabolic markers suggest functional deficiency

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Newbold, et al

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They leverage the fact that it was in human trials to imply a level of proven efficacy and safety for that purpose, which is a gross misrepresentation of the facts

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[DOI] [PMC free article] [PubMed] [Google Scholar] 50.Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjrbaek C, Flier JS

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Cobalamin deficiency should not be assumed to be due to pernicious anemia (ie, autoimmune destruction of parietal cells resulting in intrinsic factor deficiency) simply because that is the most common cause

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