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In contrast, GLP-1 QMP maintained its receptor binding irrespective of L585 cleavage (Fig

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However, pathological modifications oxidation, glycation, citrullination, carbonylation, and enzymatic carboxyethylation of cysteine (linked to ankylosing spondylitis) can render self-proteins immunogenic, driving autoimmune disease by presenting chemically altered peptides to the immune system as foreign antigens.