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As a result, fatigue is reduced and overall energy levels are improved, facilitating better daily performance

The uterosacral ligaments are also common implant sites (alternatively called the pelvic sites) ( Retrograde menstruation The most frequent accepted theory that explains the pathogenic process by which these lesions occur is the theory of retrograde menstruation, the theory that the backup of extrinsic menstrual tissues into the fallopian tubes, pelvis, and peritoneum is a driving force in the formation of endometriomal implants

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However, this would not allow distinct regulation of the two pathways to occur even given the fact that the pathways are separated within different cellular compartments

A randomized, double-blind, placebo-controlled trial involving 78 patients also found no significant reduction in NAS with silymarin therapy compared to placebo [204]

Int J Mol Sci 21: 7337, 2020